Pyrazolopyridines II: Synthesis and antibacterial screening of 6-Aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4-B]pyridine-4-carboxylic Acids

Abstract

5-Amino-3-methyl-1-phenyl-1 H-pyrazole was prepared to react with various aromatic aldehydes and pyruvic acid to afford 6-aryl-3-methyl-1-phenyl-1 H-pyrazolo[3,4-b]pyridine-4-carbxylic acids. The prepared compounds were characterized by Mass, IR, 1H, 13C NMR spectra and CHN analysis data. Various 6-aryl-3-methyl-1-phenyl-1 H-pyrazolo[3,4-b]pyridine-4- carbxylic acids synthesized during this work were also evaluated for their antibacterial activities. Some of these compounds were found to be good antibacterial agents.