Defective association of dystrophin with sarcolemmal glycoproteins in the cardiomyopathic hamster heart

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Abstract

In ventricular muscle from 30- to 60-day-old Bio 14.6 cardiomyopathic hamsters, dystrophin-associated glycoproteins of 43, 50 and 150 kDa are markedly reduced in abundance. In particular, the 50-kDa glycoprotein is totally deficient in the sareolemma of myopathic ventricular myocytes as revealed by immunofluorescence microscopy. The dystrophin-glycoprotein complex formation is defective in the cardiomyopathic hamster heart, because dystrophin and the glycoproteins behave independently when digitonin-solubilized ventricular homogenates are fractionated on wheat germ agglutinin beads or anti-dystrophin immunoaffinity beads. © 1993.

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APA

Iwata, Y., Nakamura, H., Mizuno, Y., Yoshida, M., Ozawa, E., & Shigekawa, M. (1993). Defective association of dystrophin with sarcolemmal glycoproteins in the cardiomyopathic hamster heart. FEBS Letters, 329(1–2), 227–231. https://doi.org/10.1016/0014-5793(93)80227-L

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