Accumulated damage to mitochondrial DNA (mtDNA) occurs during the ageing process and neurodegenerative disease. Here, the authors show that mtDNA copy number increases in an age-dependent manner in substantia nigra of healthy individuals, but not in individuals with Parkinson disease.
Dölle, C., Flønes, I., Nido, G. S., Miletic, H., Osuagwu, N., Kristoffersen, S., … Tzoulis, C. (2016). Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Nature Communications, 7. https://doi.org/10.1038/ncomms13548