Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-YDOM sex reversal

111Citations
Citations of this article
43Readers
Mendeley users who have this article in their library.

Abstract

The phenomenon of B6-YDOM sex reversal arises when certain variants of the Mus domesticus Y chromosome are crossed onto the genetic background of the C57BL/6J (B6) inbred mouse strain, which normally carries a Mus musculus-derived Y chromosome. While the sex reversal has been assumed to involve strain-specific variations in structure or expression of Sry, the actual cause has not been identified. Here we used in situ hybridization to study expression of Sry, and the critical downstream gene Sox9, in strains containing different chromosome combinations to investigate the cause of B6-YDOM sex reversal. Our findings establish that a delay of expression of Sry DOM relative to SryB6 underlies B6-YDOM sex reversal and provide the first molecular confirmation that Sry must act during a critical time window to appropriately activate Sox9 and effect male testis determination before the onset of the ovarian-determining pathway. © 2004 Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Bullejos, M., & Koopman, P. (2005). Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-YDOM sex reversal. Developmental Biology, 278(2), 473–481. https://doi.org/10.1016/j.ydbio.2004.11.030

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free