Mitochondria is where the bulk of the cell's ATP is produced. Mutations occur to genes coding for members of the complexes involved in energy production. Some are a result of damages to nuclear coded genes and others to mitochondrial coded genes. This review describes approaches to bring small molecules, proteins and RNA/DNA into mitochondria. The purpose is to repair damaged genes as well as to interrupt mitochondrial function including energy production, oxygen radical formation and the apoptotic pathway. © 2007 Elsevier B.V. All rights reserved.
Mukhopadhyay, A., & Weiner, H. (2007, August 10). Delivery of drugs and macromolecules to mitochondria. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2007.06.004