Denitration of L-type calcium channel

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Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCav1.2b. We report here that Cav1.2 is also subject to "denitration". Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Cav1.2 in a 1D gel assay. Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates. These findings indicate that denitration may be a physiological mechanism to restore cellular excitability during inflammation. © 2008 Federation of European Biochemical Societies.




Kang, M., & Akbarali, H. I. (2008). Denitration of L-type calcium channel. FEBS Letters, 582(20), 3033–3036.

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