Denitration of L-type calcium channel

20Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L-type calcium channel, hCav1.2b. We report here that Cav1.2 is also subject to "denitration". Cell lysates from activated macrophage-like cell line, RAW264.7 cells, reversed peroxynitrite-induced nitration of the carboxy terminus of Cav1.2 in a 1D gel assay. Tyrosine phosphorylation of the calcium channel by c-src kinase was blocked by nitration but reversed by pretreatment with RAW264.7 cell lysates. These findings indicate that denitration may be a physiological mechanism to restore cellular excitability during inflammation. © 2008 Federation of European Biochemical Societies.

Cite

CITATION STYLE

APA

Kang, M., & Akbarali, H. I. (2008). Denitration of L-type calcium channel. FEBS Letters, 582(20), 3033–3036. https://doi.org/10.1016/j.febslet.2008.07.042

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free