Deoxygedunin, a natural product with potent neurotrophic activity in mice

56Citations
Citations of this article
71Readers
Mendeley users who have this article in their library.

Abstract

Gedunin, a family of natural products from the Indian neem tree, possess a variety of biological activities. Here we report the discovery of deoxygedunin, which activates the mouse TrkB receptor and its downstream signaling cascades. Deoxygedunin is orally available and activates TrkB in mouse brain in a BDNF-independent way. Strikingly, it prevents the degeneration of vestibular ganglion in BDNF -/- pups. Moreover, deoxygedunin robustly protects rat neurons from cell death in a TrkBdependent manner. Further, administration of deoxygedunin into mice displays potent neuroprotective, anti-depressant and learning enhancement effects, all of which are mediated by the TrkB receptor. Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases. © 2010 Jang et al.

Cite

CITATION STYLE

APA

Jang, S. W., Liu, X., Chan, C. B., France, S. A., Sayeed, I., Tang, W., … Ye, K. (2010). Deoxygedunin, a natural product with potent neurotrophic activity in mice. PLoS ONE, 5(7). https://doi.org/10.1371/journal.pone.0011528

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free