To address the role of the RS domain in shuttling and how it is differentially required for constitutive and alternative splicing, Lin et al. (2005 [in the November 11 issue of Molecular Cell]) employ an elegant somatic complementation system to reveal a novel phosphorylation-dependent mechanism regulating distinct recycling pathways for SR proteins during mRNP maturation. Copyright ©2005 by Elsevier Inc.
Tenenbaum, S. A., & Aguirre-Ghiso, J. (2005, November 23). Dephosphorylation shows SR proteins the way out. Molecular Cell. https://doi.org/10.1016/j.molcel.2005.11.005