Detection and Discrimination of Non-Melanoma Skin Cancer by Multimodal Imaging

  • Heuke S
  • Vogler N
  • Meyer T
  • et al.
Citations of this article
Mendeley users who have this article in their library.


Non-melanoma skin cancer (NMSC) belongs to the most frequent human neoplasms. Its exposed location facilitates a fast ambulant treatment. However, in the clinical practice far more lesions are removed than necessary, due to the lack of an efficient pre-operational examination procedure: Standard imaging methods often do not provide a sufficient spatial resolution. The demand for an efficient in vivo imaging technique might be met in the near future by non-linear microscopy. As a first step towards this goal, the appearance of NMSC in various microspectroscopic modalities has to be defined and approaches have to be derived to distinguish healthy skin from NMSC using non-linear optical microscopy. Therefore, in this contribution the appearance of ex vivo NMSC in a combination of coherent anti-Stokes Raman scattering (CARS), second harmonic generation (SHG) and two photon excited fluorescence (TPEF) imaging—referred as multimodal imaging—is described. Analogous to H&E staining, an overview of the distinct appearances and features of basal cell and squamous cell carcinoma in the complementary modalities is derived, and is expected to boost in vivo studies of this promising technological approach.




Heuke, S., Vogler, N., Meyer, T., Akimov, D., Kluschke, F., Röwert-Huber, H.-J., … Popp, J. (2013). Detection and Discrimination of Non-Melanoma Skin Cancer by Multimodal Imaging. Healthcare, 1(1), 64–83.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free