Determination of lincomycin and tylosin residues in honey using solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization mass spectrometry

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Abstract

An analytical method for the determination of residues of the antibiotic drugs lincomycin and tylosin in honey was developed. The procedure employed a solid-phase extraction for the isolation of lincomycin and tylosin from diluted honey samples. The antibiotic residues were subsequently analyzed by reversed-phase HPLC with atmospheric pressure chemical ionization mass spectrometric detection. Average analyte recoveries for lincomycin and tylosin ranged from 84 to 107% in replicate sets of honey samples fortified with drug concentrations of 0.01, 0.5, and 10μg/g. The method detection limits were determined to be 0.007 and 0.01μg/g for lincomycin and tylosin, respectively. © 2003 Elsevier B.V. All rights reserved.

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Thompson, T. S., Noot, D. K., Calvert, J., & Pernal, S. F. (2003). Determination of lincomycin and tylosin residues in honey using solid-phase extraction and liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Journal of Chromatography A, 1020(2), 241–250. https://doi.org/10.1016/j.chroma.2003.08.095

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