In this issue of Molecular Cell, Ye et al. (2012) show an unexpected cytoplasmic assembly of Arabidopsis ARGONAUTE4/siRNA complexes and that siRNA binding could facilitate the nuclear import of mature AGO4/siRNA complexes, revealing a key regulatory process during RNA-directed DNA methylation (RdDM). © 2012 Elsevier Inc.
Stunnenberg, R., & Bühler, M. (2012, June 29). A Detour to Mature. Molecular Cell. https://doi.org/10.1016/j.molcel.2012.06.004