The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4α (HNF4α, NR2A1), is essential for viral biosynthesis in the liver. The dependency of HBV transcription on HNF4α links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability. © 2009 Li et al.
Li, L., Oropeza, C. E., Sainz, B., Uprichard, S. L., Gonzalez, F. J., & McLachlan, A. (2009). Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4α. PLoS ONE, 4(5). https://doi.org/10.1371/journal.pone.0005489