A novel approach for Parkinson’s disease detection using Vold-Kalman order filtering and machine learning algorithms

Abstract

Parkinson’s disease (PD) is the second most common neurological disorder caused by damage to dopaminergic neurons. Therefore, it is important to develop systems for early and automatic diagnosis of PD. For this purpose, a study that will contribute to the development of systems for the automatic diagnosis of PD is presented. The Electroencephalography (EEG) signals were decomposed into sub-bands using adaptive decomposition methods, such as empirical mode decomposition, variational mode decomposition, and Vold-Kalman order filtering (VKF). Various features were extracted from the sub-band decomposed signals, and the significant ones were determined by Chi-squared test. These important features were applied as input to support vector machine (SVM), fitch neural network (FNN), k-nearest neighbours (KNN), and decision trees (DT), machine learning (ML) models and classification was performed. We analysed the performance of ML models by obtaining accuracy, sensitivity, specificity, positive predictive value, negative predictive values, F1-score, false-positive rate, kappa statistics, and area under the curve. The classification process was performed for two cases: PD ON-HC and PD OFF-HC groups. The most successful method in this study was the VKF method, which was applied for the first time in this field with the approach specified for both cases. In both instances, the SVM algorithm was employed as the ML model, with classifier performance criterion values close to 100%. The results obtained in this study seem to be successful compared to the results of recent research on the diagnosis of PD.