Differences in the regulation of microtubule stability by the pro-rich region variants of microtubule-associated protein 4

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Abstract

We have recently reported a neural variant of microtubule-associated protein 4 with a short pro-rich region (MAP4-SP). Here, we show that the neural MAP4 has reduced microtubule-stabilizing activity, compared to the ubiquitous MAP4 with a long pro-rich region (MAP4-LP), both in vitro and in vivo. Fluorescence recovery after photobleaching analyses revealed that the interaction of MAP4-SP with the microtubules is very rapid, with a half-time of fluorescence recovery of 7 ± 2.36 s, compared to 19.5 ± 3.03 s in case of MAP4-LP. The dynamic interaction of MAP4-SP with microtubules in neural cells may contribute to the dynamic behaviors of extending neurites. © 2006 Federation of European Biochemical Societies.

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Hasan, M. R., Jin, M., Matsushima, K., Miyamoto, S., Kotani, S., & Nakagawa, H. (2006). Differences in the regulation of microtubule stability by the pro-rich region variants of microtubule-associated protein 4. FEBS Letters, 580(14), 3505–3510. https://doi.org/10.1016/j.febslet.2006.05.028

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