Muscarinic acetylcholine receptor (mAChR) III expressed in Xenopus oocytes, like mAChR I, mediates activation of a Ca2+-dependent Cl- current, whereas mAChR IV, like mAChR II, principally induces activation of Na+ and K+ currents in a Ca2+-independent manner. mAChR III has a sensitivity to agonist of about one order of magnitude higher than that of mAChR I in mediating the Ca2+-dependent current response in Xenopus oocytes and in stimulating phosphoinositide hydrolysis in NG108-15 neuroblastoma-glioma hybrid cells. The agonist-binding affinity of mAChR III is also about one order of magnitude higher than that of mAChR I. © 1988.
Bujo, H., Nakai, J., Kubo, T., Fukuda, K., Akiba, I., Maeda, A., … Numa, S. (1988). Different sensitivities to agonist of muscarinic acetylcholine receptor subtypes. FEBS Letters, 240(1–2), 95–100. https://doi.org/10.1016/0014-5793(88)80346-6