A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration

  • Villari G
  • Jayo A
  • Zanet J
  • et al.
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Abstract

©2015. Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers. Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo. However, potential non-actin bundling roles for fascin remain unknown.Here,we showfor the first timethat fascin can directly interact with the microtubule cytoskeleton and that this does not depend upon fascin-actin bundling. Microtubule binding contributes to fascindependent control of focal adhesion dynamics and cell migration speed. We also show that fascin forms a complex with focal adhesion kinase (FAK, also known as PTK2) and Src, and that this signalling pathway lies downstream of fascin-microtubule association in the control of adhesion stability. These findings shed light on newnon actindependent roles for fascin and might have implications for the design of therapies to target fascin in metastatic disease.

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Villari, G., Jayo, A., Zanet, J., Fitch, B., Serrels, B., Frame, M., … Parsons, M. (2015). A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration. Journal of Cell Science, 128(24), 4601–4614. https://doi.org/10.1242/jcs.175760

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