Direct interferon-γ-mediated protection caused by a recombinant coxsackievirus B3

27Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

Coxsackievirus B3 (CVB3) is one of the most important causes of viral myocarditis. Cytokines are involved in the control of CVB3 replication and pathogenesis. Local expression of specific cytokines by recombinant CVB3 confers prevention of virus-caused myocarditis. Expression of IFN-γ by CVB3(IFN-γ) protected BALB/c and C57BL/6 mice when the lethal infection with the highly pathogenic CVB3H3 variant was given directly after or prior to CVB3(IFN-γ) inoculation by decreasing the viral load and spread as well as tissue destruction. This direct effect was not restricted to the homologous virus. In vitro, cocultivation of CVB3(IFN-γ)-infected cells induced a reduction of CVB3H3 replication and virus-induced cytopathogenicity. © 2003 Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Henke, A., Zell, R., Martin, U., & Stelzner, A. (2003). Direct interferon-γ-mediated protection caused by a recombinant coxsackievirus B3. Virology, 315(2), 335–344. https://doi.org/10.1016/S0042-6822(03)00538-5

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free