Direct quantification of rare earth elements concentrations in urine of workers manufacturing cerium, lanthanum oxide ultrafine and nanoparticles by a developed and validated ICP-MS

5Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

© 2016 by the authors; licensee MDPI, Basel, Switzerland. Rare earth elements (REEs) have undergone a steady spread in several industrial, agriculture and medical applications. With the aim of exploring a sensitive and reliable indicator of estimating exposure level to REEs, a simple, accurate and specific ICP-MS method for simultaneous direct quantification of 15 REEs ( 89 Y, 139 La, 140 Ce, 141 Pr, 146 Nd, 147 Sm, 153 Eu, 157 Gd, 159 Tb, 163 Dy, 165 Ho, 166 Er, 169 Tm, 172 Yb and 175 Lu) in human urine has been developed and validated. The method showed good linearity for all REEs in human urine in the concentrations ranging from 0.001–1.000 μg • L -1 with r 2 > 0.997. The limits of detection and quantification for this method were in the range of 0.009–0.010 μg • L -1 and 0.029–0.037 μg • L -1 , the recoveries on spiked samples of the 15 REEs ranged from 93.3% to 103.0% and the relative percentage differences were less than 6.2% in duplicate samples, and the intra- and inter-day variations of the analysis were less than 1.28% and less than 0.85% for all REEs, respectively. The developed method was successfully applied to the determination of 15 REEs in 31 urine samples obtained from the control subjects and the workers engaged in work with manufacturing of ultrafine and nanoparticles containing cerium and lanthanum oxide. The results suggested that only the urinary levels of La (1.234 ± 0.626 μg • L -1 ), Ce (1.492 ± 0.995 μg • L -1 ), Nd (0.014 ± 0.009 μg • L -1 ) and Gd (0.023 ± 0.010 μg • L -1 ) among the exposed workers were significantly higher (p < 0.05) than the levels measured in the control subjects. From these, La and Ce were the primary components, and accounted for 88% of the total REEs. Lanthanum comprised 27% of the total REEs while Ce made up the majority of REE content at 61%. The remaining elements only made up 1% each, with the exception of Dy which was not detected. Comparison with the previously published data, the levels of urinary La and Ce in workers and the control subjects show a higher trend than previous reports.

Cite

CITATION STYLE

APA

Li, Y., Yu, H., Zheng, S., Miao, Y., Yin, S., Li, P., & Bian, Y. (2016). Direct quantification of rare earth elements concentrations in urine of workers manufacturing cerium, lanthanum oxide ultrafine and nanoparticles by a developed and validated ICP-MS. International Journal of Environmental Research and Public Health, 13(3). https://doi.org/10.3390/ijerph13030350

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free