Design of clinical research whose purpose is to answer questions about causality can be classified in relation to four axes: the number of study groups, the implementation of an experimental maneuver, cause-effect directionality and source from which the data are collected. The basic designs used in epidemiology are the clinical trial, the cohort study, the case-control study and the cross-sectional survey. This text aims to facilitate the identification and understanding of each of these designs through examples related to the association between rotavirus vaccination and intussusception.
Castilla-Peón, M. F., Ramírez-Sandoval, J. C., Reyes-Morales, H., & Reyes-López, A. (2015, September 1). Diseño de estudios clínicos y causalidad: ¿La vacuna oral contra rotavirus causa invaginación intestinal? Boletin Medico Del Hospital Infantil de Mexico. Masson-Doyma Mexico, S.A. https://doi.org/10.1016/j.bmhimx.2015.09.005