Disseminated Histoplasmosis in a 13-year-old girl: A case report

  • A.C. U
  • O.C. O
  • N.S. I
  • et al.
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BACKGROUND: Disseminated histoplasmosis is a rare fungal infection and most documented cases are in immune-compromised individuals such as those with acquired immuno-deficiency syndrome., OBJECTIVE: To describe a case of disseminated histoplasmosis in an adolescent girl., METHOD: We report a case of disseminated histoplasmosis in a 13-year-old adolescent girl. She was admitted for 16 days because of neck masses of 3 years duration, generalized body swelling of 3 months and reduction in urinary output of 2 months. She tested negative for human immunodeficiency virus antibodies., RESULT: An autopsy was performed because a definitive diagnosis could not be made while the patient was still alive. The autopsy revealed central caseating areas in the lymph nodes and membranoproliferative glomerulonephritis. The periodic acid-Schiff staining technique for tissues showed viable yeast cells suggestive of histoplasmosis. Zeihl-Neelsen's staining for mycobacteria tuberculosis was negative., CONCLUSION: Undiagnosed case of disseminated histoplasmosis while the patient was alive is being reported in a 13-year-old girl. Disseminated histoplasmosis should be considered as a differential diagnosis of childhood chronic infections and malignancies as in Nigeria.




A.C., U., O.C., O., N.S., I., V.O., O., N.R., M., J.C., U., … Ibe, B. (2013). Disseminated Histoplasmosis in a 13-year-old girl: A case report. African Health Sciences. A. C. Ubesie, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria. E-mail: zionagoz@yahoo.co.uk: Makerere University, Medical School (P.O. Box 7072, Kampala, Uganda). Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=prem&NEWS=N&AN=24235958

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