The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent proteasomal degradation, thereby potentially regulating reverse cholesterol transport. © 2007 Elsevier Inc. All rights reserved.
Feige, J. N., & Auwerx, J. (2007, November 7). DisSIRTing on LXR and Cholesterol Metabolism. Cell Metabolism. https://doi.org/10.1016/j.cmet.2007.10.003