The recent availability of the full Saccharomyces cerevisiae genome sequence offers a first opportunity to analyze the composition, function and evolution of GTPases in the ras-p21 superfamily. This superfamily in yeast is composed of 29 proteins divided into five families: ras with four sequences implicated in cell signalling; rho, six genes related to the cell shape machinery; ypt-rab, ten proteins with different roles in intracellular trafficking; arf-sar, seven proteins related to vesicular trafficking in secretory pathways; and ran, two proteins acting as components of the nuclear transport system. The superfamily covers a wide range of cellular functions from signalling to intracellular trafficking, while conserving the structural framework and a common mechanism of GTP hydrolysis. Copyright (C) 1998 Federation of European Biochemical Societies.
Garcia-Ranea, J. A., & Valencia, A. (1998). Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae. FEBS Letters, 434(3), 219–225. https://doi.org/10.1016/S0014-5793(98)00967-3