Previous studies have shown that two hemolytic toxins, HlyA and AerA, contribute to the virulence of Aeromonas hydrophila. A survey was performed to gauge the distribution of hlyA and aerA genes in clinical and environmental Aeromonas isolates. For A. hydrophila, A. veronii biotype sobria and A caviae, 96%, 12% and 35% of strains, respectively, were hlyA positive, whereas, 78%, 97%, 41%, respectively, were aerA positive. All virulent A. hydrophila isolates were hlyA+ aerA+. This genotype was most common in A. hydrophila (75.4%) followed by A. caviae (29.4%) and A. veronii biotype sobria (9.6%). For A. hydrophila, a two-hemolytic toxin model of virulence provides the best prediction of virulence in an animal model. Copyright (C) 1999 Federation of European Microbiological Societies.
Heuzenroeder, M. W., Wong, C. Y. F., & Flower, R. L. P. (1999). Distribution of two hemolytic toxin genes in clinical and environmental isolates of Aeromonas spp.: Correlation with virulence in a suckling mouse model. FEMS Microbiology Letters, 174(1), 131–136. https://doi.org/10.1016/S0378-1097(99)00130-5