Using a combination of genetics and cellular DNA rejoining assays, in this issue of Molecular Cell, Wyatt et al. (2016) demonstrate a critical role for mammalian DNA polymerase θ in the rejoining of DNA ends that are poor substrates for classical non-homologous end joining.
Willis, N. A., & Scully, R. (2016, August 18). DNA Polymerase θ: Duct Tape and Zip Ties for a Fragile Genome. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2016.08.006