In recent issues of Molecular Cell, Cell, and Science, Smogorzewska et al. (2010), MacKay et al. (2010), Kratz et al. (2010), and Liu et al. (2010) identify FAN1 as a nuclease that is recruited to sites of interstrand crosslinks by ubiquitylated FANCD2, where it participates in DNA repair. The identification of FAN1 fills a missing link in interstrand crosslink DNA repair. © 2010 Elsevier Inc.
O’Donnell, L., & Durocher, D. (2010, July). DNA repair has a new FAN1 club. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.07.010