DNA-binding interaction studies of microwave assisted synthesized sulfonamide substituted 8-hydroxyquinoline derivatives

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Abstract

Sulfonamide substituted 8-hydroxyquinoline derivatives were prepared using a microwave synthesizer. The interaction of sulfonamide substituted 8-hydroxyquinoline derivatives and their transition metal complexes with Plasmid (pUC 19) DNA and Calf Thymus DNA were investigated by UV spectroscopic studies and gel electrophoresis measurements. The interaction between ligand/metal complexes and DNA was carried out by increasing the concentration of DNA from 0 to 12 μl in UV spectroscopic study, while the concentration of DNA in gel electrophoresis remained constant at 10 μl. These studies supported the fact that, the complex binds to DNA by intercalation via ligand into the base pairs of DNA. The relative binding efficacy of the complexes to DNA was much higher than the binding efficacy of ligands, especially the complex of Cu-AHQMBSH had the highest binding ability to DNA. The mobility of the bands decreased as the concentration of the complex was increased, indicating that there was increase in the interaction between the metal ion and DNA. Complexes of AHQMBSH were excellent for DNA binding as compared to HQMABS. © Dixit et al.

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Dixit, R. B., Patel, T. S., Vanparia, S. F., Kunjadiya, A. P., Keharia, H. R., & Dixit, B. C. (2011). DNA-binding interaction studies of microwave assisted synthesized sulfonamide substituted 8-hydroxyquinoline derivatives. Scientia Pharmaceutica, 79(2), 293–308. https://doi.org/10.3797/scipharm.1102-16

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