Doping inorganic ions to regulate bioactivity of Ca-P coating on bioabsorbable high purity magnesium

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Performance of biomaterials was strongly affected by their surface properties and could be designed artificially to meet specific biomedical requirements. In this study, F-(F), SiO42-(Si), or HCO3-(C)-doped Ca-P coatings were fabricated by biomimetic deposition on the surface of biodegradable high-purity magnesium (HP Mg). The crystalline phases, morphologies and compositions of Ca-P coatings had been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS). The biomineralization and corrosion resistance of doped Ca-P coatings had also been investigated. The results showed that the Ca-P coating with or without doped elements mainly contained the plate-like dicalcium phosphate dehydrate (DCPD) phase. The doped F, Si, or C changed the surface morphology of Ca-P coatings after mineralization. Doped F enhanced the mineralization of Ca-P coating, and doped Si retarded the mineralization of Ca-P coating. However, H2 evolution of HP Mg discs with different Ca-P coatings was close to 0.4-0.7ml/cm2 after two-week immersion. That meant that the corrosion resistance of the Ca-P coatings with different or without doped elements did not change significantly.




Wu, H., Zhang, R., Li, X., Ni, J., Zhao, C., Song, Y., … Zhang, X. (2014). Doping inorganic ions to regulate bioactivity of Ca-P coating on bioabsorbable high purity magnesium. Progress in Natural Science: Materials International, 24(5), 479–485.

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