Recent data indicate that Gurken-mediated activation of the EGF receptor in the somatic follicle cells of the Drosophila ovary - required for dorsoventral patterning of the fly embryo - leads to cell-autonomous repression of pipe expression, suggesting that the EGF receptor signaling pathway acts directly to control pipe transcription.
Amiri, A., & Stein, D. (2002, August 6). Dorsoventral patterning: A direct route from ovary to embryo. Current Biology. https://doi.org/10.1016/S0960-9822(02)01031-X