Drug susceptibility patterns in MDR-TB patients: Challenges for future regimen design. A cross-sectional study

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Abstract

© 2015 Stagg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant tuberculosis cases, highlight the difficulties in designing universal regimen, and inform future regimen selection. Demographic and microbiological surveillance data for multidrug resistant tuberculosis cases from 2004-13 were analysed. High levels of additional resistance to currently recommended second line drugs were seen in all settings, with extensive variability between countries. Accurate drug susceptibility testing and drug susceptibility testing data are vital to inform the development of comprehensive, flexible, multidrug resistant tuberculosis guidance.

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Stagg, H. R., Brown, J., Ibraim, E., Riekstiņa, V., Viiklepp, P., Ci’rule, A., … White, P. J. (2015). Drug susceptibility patterns in MDR-TB patients: Challenges for future regimen design. A cross-sectional study. PLoS ONE, 10(11). https://doi.org/10.1371/journal.pone.0142425

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