Background: Patients with pulmonary arterial hypertension often present with a mild obstructive lung pattern, however, the functional consequences are not known. Methods: We analysed flow volume loops during exercise in 61 patients with precapillary pulmonary hypertension (PH) (age 55 +/- 14 years) in comparison with 21 patients with COPD (60 +/- 12 years), 39 patients with pulmonary fibrosis (58 +/- 11 years) and 38 healthy controls (HC) (39 +/- 15 years). Inspiratory capacity (IC) was measured at rest, and during maximum exercise (max). Results: HC exhibited a stable IC of 3.0 +/- 0.9 l at rest, and at max. A reduction in IC of 2.6 +/- 0.8 l at rest to 2.0 +/- 0.7 l at max was observed in patients with COPD. Patients with PH exhibited a significant reduction in IC from 2.3 +/- 0.6 l at rest to 2.1 +/- 0.6 l at max, while patients with pulmonary fibrosis exhibited a stable IC of 1.8 +/- 0.6 at rest and 1.7 +/- 0.6 l at max. In patients with PH, a weak negative correlation was drawn between the change in IC (%) and peak VO2 (r = -0.29, p = 0.01), as well as with PVR (r = -0.27, p = 0.02). Conclusion: Patients with PH demonstrate a characteristic change in IC during exercise, which might contribute to impaired exercise tolerance. © 2011 Elsevier Ltd. All rights reserved.
M.J., R., R., V., H., T., R., S., C., T., A., F., … F., R. (2012). Dynamic hyperinflation during exercise in patients with precapillary pulmonary hypertension. Respiratory Medicine. F. Reichenberger, University of Giessen Lung Center, University Hospital Giessen, Klinikstrasse 33, 35392 Giessen, Germany. E-mail: Frank.Reichenberger@innere.med.uni-giessen.de: W.B. Saunders Ltd (32 Jamestown Road, London NW1 7BY, United Kingdom). Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed10&NEWS=N&AN=2012001857