Dynamic Input Conductances Shape Neuronal Spiking

  • Drion G
  • Franci A
  • Dethier J
  • et al.
Citations of this article
Mendeley users who have this article in their library.


© 2015 Drion et al. Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness, and homeostasis of neuronal signalling. The paper proposes that this question can be addressed through the analysis of dynamic input conductances. Those voltage-dependent curves aggregate the concomitant activity of all ion channels in distinct timescales. They are shown to shape the current−voltage dynamical relationships that determine neuronal spiking. We propose an experimental protocol to measure dynamic input conductances in neurons. In addition, we provide a computational method to extract dynamic input conductances from arbitrary conductance-based models and to analyze their sensitivity to arbitrary parameters. We illustrate the relevance of the proposed approach for modulation, compensation, and robustness studies in a published neuron model based on data of the stomatogastric ganglion of the crab Cancer borealis.




Drion, G., Franci, A., Dethier, J., & Sepulchre, R. (2015). Dynamic Input Conductances Shape Neuronal Spiking. ENeuro, 2(1). https://doi.org/10.1523/ENEURO.0031-14.2015

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free