Dynamical changes in neurological diseases and anesthesia

18Citations
Citations of this article
70Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Dynamics of neuronal networks can be altered in at least two ways: by changes in connectivity, that is, the physical architecture of the network, or changes in the amplitudes and kinetics of the intrinsic and synaptic currents within and between the elements making up a network. We argue that the latter changes are often overlooked as sources of alterations in network behavior when there are also structural (connectivity) abnormalities present; indeed, they may even give rise to the structural changes observed in these states. Here we look at two clinically relevant states (Parkinson's disease and schizophrenia) and argue that non-structural changes are important in the development of abnormal dynamics within the networks known to be relevant to each disorder. We also discuss anesthesia, since it is entirely acute, thus illustrating the potent effects of changes in synaptic and intrinsic membrane currents in the absence of structural alteration. In each of these, we focus on the role of changes in GABAergic function within microcircuits, stressing literature within the last few years. © 2012.

Cite

CITATION STYLE

APA

McCarthy, M. M., Ching, S. N., Whittington, M. A., & Kopell, N. (2012, August). Dynamical changes in neurological diseases and anesthesia. Current Opinion in Neurobiology. https://doi.org/10.1016/j.conb.2012.02.009

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free