In a longitudinal study, anti-Pfs230 and Pfs48/45 antibodies developed rapidly after exposure to gametocytes and were strongly associated with transmission-reducing activity. Our data indicate that the extent of antigen exposure is important in eliciting functional transmission-reducing immune responses.
Bousema, T., Roeffen, W., Meijerink, H., Mwerinde, H., Mwakalinga, S., van Gemert, G. J., … Drakeley, C. (2010). The dynamics of naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs230 & Pfs48/45 in a low endemic area in Tanzania. PLoS ONE, 5(11). https://doi.org/10.1371/journal.pone.0014114