The dynamics of striatum circuitry.

  • Lin S
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Comments on an article by Henry H. Yin et al. (see record [rid]2009-02743-016[/rid]). Behavioral evidence indicates that motor skill learning takes place over an initial phase of fast improvements, followed by a slower phase of gradual refinement. Recently, the roles of different striatal subregions in reward-guided instrumental learning have been extensively investigated. Two subregions of the striatum, specifically the dorsomedial striatum (DMS) and the dorsolateral striatum (DLS), have been shown to play crucial roles in the learning of goal-directed actions and habit, respectively. The authors provided an elegant example in dissecting circuit mechanisms of behavior through behavioral testing, in vivo multi-site extracellular recording, ex vivo slice physiology studies and mouse genetics tools. This combination of converging approaches leads to novel insights on the circuit mechanisms of motor skill learning with single neuron resolution and pathway-specificity, and serve as a model to tackle circuit-level mechanisms in other neural systems. (PsycINFO Database Record (c) 2016 APA, all rights reserved)




Lin, S.-C. (2010). The dynamics of striatum circuitry. Frontiers in Integrative Neuroscience, 4, 3.

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