Isothiocyanate-functionalized mesoporous silica nanoparticles as building blocks for the design of nanovehicles with optimized drug release profile

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Abstract

A straightforward methodology for the synthesis of isothiocyanate-functionalized mesoporous silica nanoparticles (MSNs) by exposure of aminated MSNs to 1,1′-thiocarbonyldi-2(1H)-pyridone is reported. These nanoparticles are chemically stable, water tolerant, and readily react with primary amines without the formation of any by-product. This feature allows the easy modification of the surface of the nanoparticles for tuning their physical properties and the introduction of gatekeepers on the pore outlets. As a proof-of-concept, amino-isothiocyanate-functionalized MSNs have been used for the design of a nanocontainer able to release the drug Ataluren. The release profile of the drug can be easily fine-tuned with the careful choice of the capping amine.

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Martínez-Edo, G., Llinàs, M. C., Borrós, S., & Sánchez-García, D. (2019). Isothiocyanate-functionalized mesoporous silica nanoparticles as building blocks for the design of nanovehicles with optimized drug release profile. Nanomaterials, 9(9). https://doi.org/10.3390/nano9091219

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