Study on DNA precipitation with a cationic polymer PAC (poly aluminuim chloride).

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Abstract

We studied on the interactions between DNA and polyaluminuimchloride (PAC) by ultraviolet spectroscopy and electron microscopy to understand the interaction between negative-charged macromolecules and PAC. Sodium ion seems to have only weak effect on the manner of DNA/PAC complex. However, acetate and phosphate anions competed against phosphate in DNA for interaction with PAC. It seems that negative macromolecule in a water system may be similar behavior with DNA under PAC.

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Matsuzawa, Y., & Hiraishi, A. (2003). Study on DNA precipitation with a cationic polymer PAC (poly aluminuim chloride). Nucleic Acids Research. Supplement (2001), (3), 163–164. https://doi.org/10.1093/nass/3.1.163

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