One-pot combination of metal- and bio-catalysis in water for the synthesis of Chiral molecules

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Abstract

During the last decade, the combination of different metal- and bio-catalyzed organic reactions in aqueous media has permitted the flourishing of a variety of one-pot asymmetric multi-catalytic reactions devoted to the construction of enantiopure and high added-value chemicals under mild reaction conditions (usually room temperature) and in the presence of air. Herein, a comprehensive account of the state-of-the-art in the development of catalytic networks by combining metallic and biological catalysts in aqueous media (the natural environment of enzymes) is presented. Among others, the combination of metal-catalyzed isomerizations, cycloadditions, hydrations, olefin metathesis, oxidations, C-C cross-coupling and hydrogenation reactions, with several biocatalyzed transformations of organic groups (enzymatic reduction, epoxidation, halogenation or ester hydrolysis), are discussed.

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Ríos-Lombardía, N., García-Álvarez, J., & González-Sabín, J. (2018, February 10). One-pot combination of metal- and bio-catalysis in water for the synthesis of Chiral molecules. Catalysts. MDPI AG. https://doi.org/10.3390/catal8020075

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