Synthesis induced by microwave irradiatio and in vitro antifungal evaluation of new dihydropyrazolo[3,4-b] [1,4]diazepines

Abstract

New 2- and 4-methylenedioxyphenyl-8-phenyl-2,3-dihydropyrazolo[3,4-b] diazepines 3 were obtained from the reaction of 4,5-diamino-3-methyl-1- phenylpyrazole 1 with one equivalent of the methylenedioxychalcones 2 in both absolute ethanol and under solvent-free conditions microwave irradiation. The structures of diazepines 3 were determined by detailed nmr measurements. These compounds does not showed any antifungal in vitro activity up to 250 μg/ml.