Lightening the Load: The Relationship Between Gait and Cognition for Persons Living with Dementia Engaged in a Non-Pharmacological Intervention

Abstract

Objectives: Relatively little research has explored whether gait and cognition are systematically associated within-persons across time, especially in persons living with dementia (PLwD). Understanding a shared mechanism between gait and cognition may help elucidate effective intervention strategies for promoting cognitive and physiological health in PLwD simultaneously. Methods: 33 PLwD enrolled in an 18-month choral intervention employing a measurement-burst design that facilitated up to 9 assessments per person. Three-level multilevel models investigated the time-varying covariation between cognition and gait velocity (indexed using a GAITRite computerized walkway) under both a walk-only and dual-task condition. Results: Significant coupling was observed between gait velocity and MMSE (mini-mental state examination) under the dual-task condition, indicating that, on occasions when an individual’s MMSE was one-unit greater than their personal average, there was a corresponding increase in dual-task gait velocity. Conclusions: This study highlights a shared within-person mechanism through which improvements in cognition may facilitate physiological advantages.