Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in obesity. In this review, we focus on obesity-associated changes in inflammation, metabolism, and impaired insulin signaling, which are pathologically dysregulated and ultimately result in a loss of muscle mass and function. In addition, we examine the relationships between skeletal muscle, liver, and visceral adipose tissue in an obese state.
Sinha, I., Sakthivel, D., & Varon, D. E. (2017, February 16). Systemic regulators of skeletal muscle regeneration in obesity. Frontiers in Endocrinology. Frontiers Research Foundation. https://doi.org/10.3389/fendo.2017.00029