Is TWEAK a biomarker for autoimmune/chronic inflammatory diseases?

20Citations
Citations of this article
27Readers
Mendeley users who have this article in their library.

Abstract

The TWEAK/Fn14 pathway is now well-known for its involvement in the modulation of inflammation in various human autoimmune/chronic inflammatory diseases (AICID) including lupus, rheumatoid arthritis, and multiple sclerosis. A panel of data is now available concerning TWEAK expression in tissues or biological fluids of patients suffering from AICID, suggesting that it could be a promising biological marker in these diseases. Evidences from several teams support the hypothesis that blocking TWEAK/Fn14 pathway is an attractive new therapeutic lead in such diseases and clinical trials with anti-TWEAK-blocking antibodies are in progress. In this mini-review we discuss the potential use of TWEAK quantification in AICD management in routine practice and highlight the challenge of standardizing data collection to better estimate the clinical utility of such a biological parameter. © 2013 Bertin, Stephan, Khrestchatisky and Desplat-Jégo.

Cite

CITATION STYLE

APA

Bertin, D., Stephan, D., Khrestchatisky, M., & Desplat-Jégo, S. (2013). Is TWEAK a biomarker for autoimmune/chronic inflammatory diseases? Frontiers in Immunology. Frontiers Media SA. https://doi.org/10.3389/fimmu.2013.00489

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free