Postoperative adhesiolysis therapy for intrauterine adhesions (Asherman's syndrome)

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Objective: To evaluate postoperative blunt adhesiolysis after sharp adhesiolysis for the treatment of intrauterine adhesions. Design: Retrospective analysis of 24 patients treated with primary hysteroscopic adhesiolysis followed by hormone therapy and serial flexible office hysteroscopy (Canadian Task Force Classification II-3). Setting: University-affiliated community hospital. Patient(s): Twenty-four women with menstrual disorders, pain, or infertility resulting from intrauterine adhesions. Intervention(s): Serial, postoperative, hysteroscopic blunt adhesiolysis of recurrent synechiae. Main Outcome Measure(s): Restoration of normal menstrual pattern, relief of dysmenorrhea, improvement in fertility, and improvement in stage of disease. Result(s): Eighty-three percent of patients (20/24) presented with amenorrhea or oligomenorrhea, 67% (16/24) had either infertility or recurrent miscarriages, and 54% (13/24) presented with dysmenorrhea. Initially, 50% (12/24) had severe adhesions, 46% (11/24) moderate, and 4% (1/24) minimal disease according to the March criteria. Improvement in menstrual flow occurred in 95% (18/19) of patients, relief of dysmenorrhea occurred in 92% (12/13), and 46% (7/15) of fertility patients were actively pregnant or had delivered viable infants at the conclusion of the study. There was a 92% (22/24) improvement in disease staging over the treatment interval. Conclusion(s): Blunt adhesiolysis with a flexible hysteroscope is effective for maintenance of cavity patency after primary treatment of intrauterine adhesions. © 2008 American Society for Reproductive Medicine.




Robinson, J. K., Colimon, L. M. S., & Isaacson, K. B. (2008). Postoperative adhesiolysis therapy for intrauterine adhesions (Asherman’s syndrome). Fertility and Sterility, 90(2), 409–414.

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