Beyond the epithelium: Cadherin function in fibrous connective tissues

29Citations
Citations of this article
44Readers
Mendeley users who have this article in their library.

Abstract

In fibrous connective tissues, fibroblasts are organized into syncytia, cellular networks that enable matrix remodeling and that are interconnected by intercellular adherens junctions (AJs). The AJs of fibroblasts are mediated by N-cadherin, a broadly expressed classical cadherin that is critically involved in developmental processes, wound healing and several diseases of mesenchymal tissues. In contrast to E-cadherin-dependent junctions of epithelia, the formation of AJs in fibrous connective tissues is relatively uncharacterized. Work over the last several years has documented an expanding list of molecules which function to regulate N-cadherin mediated junctions such as: Fer, PTP1B, cortactin, calcium, gelsolin, PIP5KIγ, PIP2, and the Rho family of GTPases. We present an overview on the regulation of N-cadherin-mediated junction formation that highlights recent molecular advances in the field and rationalizes the roles of N-cadherin in connective tissue function. © 2006 Federation of European Biochemical Societies.

Cite

CITATION STYLE

APA

El Sayegh, T. Y., Kapus, A., & McCulloch, C. A. (2007, January 23). Beyond the epithelium: Cadherin function in fibrous connective tissues. FEBS Letters. https://doi.org/10.1016/j.febslet.2006.12.029

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free