Placentation in the African elephant, Loxodonta africana. IV. Growth and function of the fetal gonads

Abstract

The gonads, both ovaries and testes, of 44 elephant fetuses weighing 0.09-112 kg (6.1 -21.3 months gestation) were examined grossly and histologically. As in equids, elephant fetal gonads undergo a phase of marked growth and enlargement during the second half of gestation, which is more pronounced in ovaries than testes due to growth and antrum formation of numerous follicles in the former. Stromal cells undergo hypertrophy and transformation to form zones of interstitial cells that are associated with the enlarged follicles in the ovaries and in which the primitive seminiferous tubules are embedded in the testes. The interstitial cells have the capacity to synthesize 5α-dihydroprogesterone and other 5α-reduced progestagens from cholesterol and pregnenelone and the hypothesis is raised that these fetal gonadal progestagens may supplement significantly the progestagens secreted by the multiple large corpora lutea of pregnancy in the elephant. © 2005 Society for Reproduction and Fertility.