Diabetes during pregnancy among Métis people in Alberta: a retrospective cohort study

Abstract

Background: Diabetes in pregnancy is an important public health concern for Indigenous populations. We sought to evaluate the prevalence and outcomes of preexisting and gestational diabetes among Métis pregnancies compared with other pregnancies in Alberta, Canada. Methods: We conducted a retrospective cohort study using administrative health data from 2006 to 2016 and the Métis Nation of Alberta Identification Registry to compare the prevalence of preexisting and gestational diabetes among all singleton Métis births with nonMétis births. We compared 10 maternal and neonatal outcomes using adjusted odds ratios (ORs) and 95% confidence intervals (CIs) in multivariable analyses. Results: The study population included 7902 Métis and 471 886 nonMétis births. The agestandardized prevalence of preexisting diabetes was 1.7% (95% CI 1.4%–2.1%) for Métis and 1.1% (95% CI 1.1%–1.2%) for nonMétis pregnancies. For gestational diabetes, the agestandardized prevalence was 6.3% (95% CI 5.6%–6.9%) for Métis and 5.4% (95% CI 5.3%–5.4%) for nonMétis pregnancies. After adjusting for parity, maternal weight, age, smoking during pregnancy and material and social deprivation, Métis pregnancies had 1.72 times higher prevalence of preexisting diabetes (adjusted OR 1.72, 95% CI 1.15–2.56) and 1.30 times higher prevalence of gestational diabetes (adjusted OR 1.30, 95% CI 1.08–1.57) than nonMétis pregnancies. Métis pregnancies with preexisting diabetes had nearly 3 times the odds of developing preeclampsia (adjusted OR 2.96, 95% CI 1.27–6.90), while those with gestational diabetes had 48% higher odds of largeforgestationalage infants (adjusted OR 1.48, 95% CI 1.00–2.19). Interpretation: Métis pregnancies have an increased prevalence of preexisting and gestational diabetes than nonMétis pregnancies and an elevated risk of some perinatal outcomes. Interventions to tackle these health inequities should address both physiologic and cultural dimensions of health, informed by Métis perspectives.