ADVANCEMENT OF TOTAL PHYTOCONSTITUENT EXTRACTION PROCESS BY NEW WAY FACTOR ANALYSIS FOR TRIDAX PROCUMBENS L.

Abstract

The majority of literature hails the potential of natural products, and their derivs. are still in the forefront of drug discovery. In spite of the exceptional success of natural products in the history of drug development, some voices which have pointed out significant challenges such as extn. time, low yields, limited supply, and complex structures precluding practical synthesis. In this work, we added fuel to extn. challenges through focusing on extn. end time identification using correlation studies of numerous factors for the Tridax procumbens aq. leave ext. The factorial anal. resulted that six factors such as temp., microwave irradn. power, absorbance, Oxidn./redn. potential, and total dissolved solids are most useful to the description of extn. end time except pH and vol. water displacement. The correlation study between yield and microwave irradn. power quantified that more yield obtained at a 7-microwave power between 30-40 min with 80 °C temp. A pos. correlation (r2) of favorable factors are directly proportional to the yield of ext. and the total phytoconstituents extn. end at 30th to 40th minute interval in microwave 7 power. Further microwave irradn. leads to degrdn. of phytoconstituents. The results concluded that this new way anal. specifies the extn. end time of phytoconstituent with the lead of shorter extn. time, minimal solvent usage, and higher yield. These findings were shed light to the furthering of natural product discovery endeavors through uprooting bottlenecks. [on SciFinder(R)]