Solubility method using static head-space gas chromatography for determination of the stability constants of fragrance materials with 2- hydroxypropyl-β-cyclodextrin

Abstract

The stability constants for the inclusion of fragrance materials with 2- hydroxypropyl-β-cyclodextrin (2HPβ-CyD) in aqueous solution have been determined at 25°C by a solubility method. The solubility of fragrance in 2HP-β-CyD solution was determined from the concentration of fragrance in vapor which was in equilibrium with that in the solution using static head- space gas chromatography (SHSGC). The stability constants of (+)-limonene and linalool obtained by this method were in rough accord with the reported values. Because of its advantages of simplicity, less amount of guest used and the ease of temperature control, it was concluded that the SHSGC method is another useful technique for determining the solubility and stability constant of a volatile guest/CyD system in aqueous medium.