The Emerging Role of Hedgehog Signaling in Viral Infections

6Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

The hedgehog (HH) signaling pathway is one of the key pathways that is indispensable for many developmental processes and postnatal tissue homeostasis. Dysregulated HH signaling could lead to developmental disorders and tumorigenesis in a variety of tissues via inherited or sporadic mutation, gene overexpression, and crosstalk with other signaling pathways. Recently, accumulating evidence has shown that HH signaling is targeted by viruses to facilitate viral transcription, immune evasion, and uncontrolled growth, leading to effective viral replication and pathogenesis. In this study, we will summarize recent advances in functional interaction between HH signaling and different types of viruses, particularly focusing on the pathological role of HH signaling in viral infections and related diseases.

Cite

CITATION STYLE

APA

Zhou, Y., Huang, J., Jin, B., He, S., Dang, Y., Zhao, T., & Jin, Z. (2022, April 8). The Emerging Role of Hedgehog Signaling in Viral Infections. Frontiers in Microbiology. Frontiers Media S.A. https://doi.org/10.3389/fmicb.2022.870316

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free