TyG-WC Index as a Superior Predictor of Hyperuricemia Risk in the Hypertensive Population: A Prospective Cohort Study

Abstract

Objective: To evaluate the predictive value of the triglyceride-glucose waist circumference index (TyG-WC) for hyperuricemi(HUA) risk in the hypertensive population. Methods: This prospective cohort study involved 831 hypertensive patients with normal uric acid levels, who underwent continuouhealth examinations for five years. Participants were categorized into four groups based on baseline TyG-WC quartiles, and thincidence of hyperuricemia was monitored in each group. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for HUA incidence were calculated using Cox proportional hazards regression analysis. The predictive ability of various TyG indices for HUA was evaluated using receiver operating characteristic curves. Results: After five years of follow-up, 117 participants developed HUA. The cumulative incidence of HUA was significantly higher ithe highest TyG-WC quartile (Q4) compared to the lowest quartile (Q1). The TyG-WC index demonstrated the highest predictivvalue, with an area under the curve of 0.685 (95% CI: 0.635–0.734) compared to other obesity-related TyG indices. After adjusting foconfounding factors, per standard deviation increase in the TyG-WC index was associated with a 1.28-fold higher risk of developinHUA (95% CI: 1.04–1.56, P < 0.001). Conclusion: The TyG-WC index is a robust independent predictor of HUA risk in the hypertensive population. It provides a practicareliable, and cost-effective tool for the early identification of high-risk individuals in this population.