Infliximab, a monoclonal antibody directed against tumour necrosis factor-alpha, is an effective therapy for Crohn's disease. Though uncommon, serious opportunistic infections, including reactivation of tuberculosis, have occurred in patients after infliximab administration. Meningitis caused by Listeria monocytogenes developed in a 37-year-old man six days after the second infusion of infliximab. The patient, who also was treated with azathioprine and corticosteroids, had an uneventful recovery after a course of antibiotics. Several other recent reports have implicated infliximab therapy in the development of severe Listeria infections, particularly meningitis and sepsis. With the increasing use of tumour necrosis factor-alpha-neutralizing agents, clinicians should be aware of the risk of opportunistic infections caused by L monocytogenes in patients with Crohn's disease following infliximab treatment. ©2005 Pulsus Group Inc. All rights reserved.
CITATION STYLE
Williams, G., Khan, A. A., & Schweiger, F. (2005). Listeria meningitis complicating infliximab treatment for Crohn’s disease. Canadian Journal of Infectious Diseases and Medical Microbiology, 16(5), 289–292. https://doi.org/10.1155/2005/814698
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